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本帖最后由 L.Emperor 于 2018-7-27 13:44 编辑
The proteasome subcomponents are often referred to by their Svedberg sedimentation coefficient (denoted S). The proteasome most exclusively used in mammals is the cytosolic 26S proteasome, which is about 2,000 kilodaltons (kDa) in molecular mass containing one 20S protein subunit and two 19S regulatory cap subunits.
The core is hollow and provides an enclosed cavity in which proteins are degraded; openings at the two ends of the core allow the target protein to enter. Each end of the core particle associates with a 19S regulatory subunit that contains multiple ATPase active sites and ubiquitin binding sites; it is this structure that recognizes polyubiquitinated proteins and transfers them to the catalytic core. An alternative form of regulatory subunit called the 11S particle can associate with the core in essentially the same manner as the 19S particle; the 11S may play a role in degradation of foreign peptides such as those produced after infection by a virus.
感谢楼主分享~~~
感谢楼主分享~~~
楼主好人
这么福利的东西都没多少人看么？感谢分享~
挺不错的，谢谢分享~~~{:11_494:}
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感谢楼主分享。。。